Microbubble Contrast Agents
Current ultrasound contrast agents are made by phospholipid-shelled monolayer microbubbles. These bubbles have a very small particle size that could make them pass through the pulmonary system and circulate in the whole body. Based on the acoustic impedance mismatch, bubbles enhance the signal intensity of backscattered ultrasound helping physicians to clearly visualize small blood vessels in an ultrasound scanning. After the six-year R & D, TRUST Bio-sonics has successfully identified the key factors to control the particle size of the bubble. Through precisely adjusting the lipid formulations, TRUST Bio-sonics commercialized the microbubble agent with the smallest particle sizes. This series of microbubbles contrast agent has the features of low risk of local embolism, high imaging resolution and high contrast enhancement of tumors. These characteristics assist physicians to collect detail perfusion information and practice quantitative diagnosis in a contrast-enhanced ultrasound imaging (CEUS).